You also will find educational materials and fun games and activities to help educate children about the dangers of heat. This website is designed to prepare you for excessive heat events, describe what to do during a an excessive heat wave, and inform you about the health dangers of heat. Information and resources in both English and Spanish from the National Highway Traffic Safety Administration. NWS Safety information on Children, Pets and Vehicles: Find out more about how cars can heat up quickly when left in the sun. Deaths routinely are reported as early as April and tragedies continue into December in southern states. To see the latest information for 2023, go to this link. Kids play in cars or wander outside and get into a car and can die in 10 minutes! A reported 33 children died in hot cars in 2022. If you have a toddler in your household, lock your cars, even in your own driveway. It is NEVER safe to leave a child, disabled person or pet locked in a car, even in the winter. Pregnant women are also at higher risk. Extreme heat events have been associated with adverse birth outcomes such as low birth weight, preterm birth, and infant mortality, as well as congenital cataracts.People with chronic medical conditions are more likely to have a serious health problem during a heat wave than healthy people.Older adults, particularly those with pre existing diseases, take certain medications, are living alone or with limited mobility who are exposed to extreme heat can experience multiple adverse effects.Young children and infants are particularly vulnerable to heat-related illness and death, as their bodies are less able to adapt to heat than are adults.According to The Impacts Of Climate Change On Human Health In The United States: A Scientific Assessment the following groups are particularly vulnerable to heat check in with friends and relatives who fall in one of these populations, especially if they don’t have air conditioning. Everyone can be vulnerable to heat, but some more so than others. Heat can be very taxing on the body check out the heat related illnesses that can occur with even a short period of exposure. Heat is one of the leading weather-related killers in the United States, resulting in over one thousand fatalities each year, per the CDC.
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Just like in Equation 1, let’s let x represent the number of years after 2014.This question tests your ability to write linear expressions, differentiate between equations and inequalities, and translate word problems into equations.Typically, the phrase “at least” indicates that you’ll be utilizing an inequality rather than an expression or equation.Before we get started, let’s recognize a keyword-phrase hint: “At least.”.Let’s break down this linear equation-based word problem and start off with what we know!.At this rate, in which year will County X have at least 1,000 miles of paved roads? (Assume that no paved roads go out of service.) Starting in 2015, the county has been building 8 miles of new paved roads each year. In 2014, County X had 783 miles of paved roads. ⇒ From here, we can plug this value into our linear expression! ⇒ Glad you asked! Since x is the number of years after 2014, a quick calculation of 2030 (the year of interest) - 2014 (the current year), tells us that x = 16. ⇒ Since we already have 783 miles, the number of miles of paved roads in 2030 can be represented by 783 + 8*x, but what is x? ⇒ Each year after 2014 (where the number of miles of paved roads has already been determined) can be represented with the variable x. Our second step is to write our linear equation.Since this problem asks how many miles of paved road the county will have in 2030, our unknown variable will be the number of years after 2014! Our first step is to conclude which variables we need to define (also referred to as the variable we need to solve for!).Let’s break down this linear equation-based word problem and start with what we know!.At this rate, how many miles of paved road will County X have in 2030? (Assume that no paved roads go out of service.)
And it’s a particularly painful one to fix once the cabinets are installed. This mistake has been made too many times. 3: Not putting spacers next to wall for fridge door opening It’s an option, just not a particularly finished look. If you select the 30” height panel, keep in mind that you will have a gap beneath the end of your cabinet box and will need to wrap the toe kick around. This will be oversized on height, allowing you or your installer to cut it to the correct height on site. In most cases you’ll want a full height end panel, meaning you’ll want to select the 36” height panel. This means that the total height from the finished floor to the top of the Ikea box will be around 34.5”, not 30”! When you select end panels, make sure you keep this in mind. But keep in mind that your base cabinet box will be sitting on top of legs, typically 4.5” high. And don’t worry too much - you can always swap the hinges if you find that you’ve used the wrong ones.Ģ: Using the wrong length panels at end of cabinets (36” not 30” panel)Īll Ikea base cabinets are 30” tall. Knowing just these two points will make picking your hinges much easier. To put it differently, you’ll need the 153° hinge if you have drawers behind your cabinet drawer. What’s different about this hinge is that when the cabinet door swings open, it also fully swings out of the way so that any drawers can be opened without the drawers hitting the open cabinet door. This is a much more substantial looking hinge. The second most commonly used hinge is the Utrusta 153°. That said, there are cases where your project will require a different hinge. And little known fact: this hinge, like most of Ikea’s cabinet hardware, is built in Austria by Blum, which makes truly world class products. It has adjustability in all three axes, making alignment easy. It’s a great hinge: it has a built in damper, in other words, it’s soft closing. The Utrusta 110° hinge is the workhorse that is also the right hinge in about 90% of cases. There are two main hinges that you’ll use on an Ikea cabinet project. So, like a toddler put in timeout for misbehaving, the South was put under military occupation until she learned to behave herself and treat black people like actual human beings. He just… got cold feet at a Westerosi wedding. Plus the pairing of Eddie Murphy and Martin Lawrence works well bouncing off each other with out trying to out do each other.He’s not dead, per se. "Life" is truly one of the most enjoyable modern comedies which rely on an equal balance of story, sentiment and humour to make it a very good movie. What this all boils down to is that if I was going to try and compare "Life" to other movies, I would put it in-between "Stir Crazy" and "The Shawshank Redemption", as it is not as funny as "Stir Crazy" and not as serious as "The Shawshank Redemption". Kelly providing songs for the movie, I can honestly say that the soundtrack is very enjoyable. The soundtrack to "Life" is very diverse but is also very good and helps set the period, there are some very nice bluesy numbers but it also has some lovely beautiful numbers. Along with this, the makeup department had to deal with ageing several stars of the movie and they have done this equally realistically. There are no huge special effects or breathtaking shots which will take your breath away he has relied on the story and performances to make the movie work.Īn important factor of "Life" is that it spans over 60 years, and in doing so the costume designers and scene decorators have done a great job of recreating each era very realistically. Another reason why he has done such a good job is that he has kept it simple. With such a cast he could have easily just let the humour run riot and forget about the story, but he has shown restraint and in doing so has let the script work it's magic. "Life" is directed by Ted Demme, who has done a more than adequate job of making a very good comedy. The best thing about the cast in "Life" is that no one tries to steal the limelight and that leaves the main star of the movie to be the story. and Bernie Mac who always give very good performances. It's by no means great acting but both Eddie Murphy and Martin Lawrence show another side to them which helps endear their funny characters to us.Īll the supporting cast do good jobs at keeping things moving, but special mention should go to Miguel A. So I was surprised to watch "Life" and see some enjoyable performances that although used there comic talents to maximum effect, it also showed them both as more than capable actors who could display a whole range of emotions. Too be honest I have never been a fan of either as the movies I have seen them in seem to rely on there loudness rather than acting skills. The lead stars in "Life" are Eddie Murphy and Martin Lawrence. One of my favourite is when Ray is describing the Night Club he wants to own "Ray's Boom Boom Room", all the prisoners who are listening can imagine themselves at the Club, it is one of the most uplifting and funny scenes I have seen in a while and quite surprising for what could have been just another comedy. "Life" could have easily ended up just a movie to showcase the comic talents of Eddie Murphy and Martin Lawrence, but instead it has a sentimental side with a nice story and many very funny scenes. But on the trip, they are incorrectly accused of murder, and are both sentenced to life in prison where they end up becoming best of friends, desperate to get out. For completely different reasons, they get in trouble with the Bar owner and are forced to go on a Boot Legging run across Mississippi to get them off the hook. In 1930's New York, Ray Gibson ( Eddie Murphy - Doctor Dolittle) is a small time con artist and pick pocket who one night in a New York bar picks the pocket of straight laced Claude Banks ( Martin Lawrence - Bad Boys). It sounds a perfect idea for a serious drama, even a little bit " Shawshank" but it is in fact a half decent comedy, which uses the comic talents of Eddie Murphy and Martin Lawrence to provide some over the top amusement in a prison setting. Murphy & Lawrence Share a Life to be Laughed atįrom the plot outline, "Life" sounds a bit weak as you would think it was all about an illegal booze run, in fact "Life" is all about the growing friendship of two men who together overcome everything that is thrown at them whilst in prison. Spiked Beetles in The Minish Cap appear identically to their appearance in Four Swords. The Minish Cap Spiked Beetle ( Figurine from The Minish Cap) They are found in the Chambers of Insight, the Sea of Trees, Death Mountain, and Vaati's Palace, as well as the Realm of Memories and the Hero's Trial. They appear slightly more reminiscent of Spinies from the Mario series, being shelled reptilian creatures. The Shield remains the only item that can flip them over, and is typically provided near areas where Spiked Beetles can be found. Spiked Beetles in Four Swords behave similarly to their previous incarnations, though they withdraw into their shells and spin at the Links while homing in on them rather than charging in straight lines. They are found in the Wing Dungeon and the Hero's Cave. Link can also use or shoot Gale Seeds at them, warping them out of the room. They can be flipped over with the Shield as before however, they can also be flipped over with the Shovel. When Link comes into their view, they will charge at him in a straight line. Spiked Beetles in Oracle of Ages appear identically to their appearance in Link's Awakening. They are found in Poison Moth's Lair, Dancing Dragon Dungeon, the Ancient Ruins, the Sword & Shield Maze, and the Hero's Cave. Spiked Beetles in Oracle of Seasons appear identically to their appearance in Link's Awakening. The Legend of Zelda: Breath Of The Wild - The Champions' Ballad Review If left alone, they will eventually flip back onto their feet. Only by blocking their attack with the Shield can they be flipped over, exposing their weak underbellies. When they are upright, they are completely invulnerable to all attacks. They slowly crawl about the room, immediately dashing towards Link in a straight line to attack when they spot him. Spinies in Link's Awakening inhabit Dungeons they are found in Tail Cave, Bottle Grotto, and Angler's Tunnel. Their charges can be defended against with the Shield, which also flips them over however, a number of other items can also be used to flip them over, such as the Cane of Pacci and the Shovel. These shells block most attacks however, if a Spiked Beetle is flipped over, its vulnerable underbelly is exposed. They normally crawl around rooms, charging towards Link and attempting to crash into him with their spiked shells. Their appearance, as well as their Japanese name Togezō, are based on the Spinies from the Mario series, to the point where their English name later aligned with the Mario characters in Link's Awakening for Nintendo Switch. Spiked Beetles are turtle-like creatures with pointed spikes on their shells. Whereas its predecessor was famous for its rollerblading, it appears Bomb Rush Cyberfunk has ditched the wheels, replacing them with…feet, apparently opting for a modern parkour approach. Upon studying those screenshots it appears there’s one glaring difference that sets it apart from Jet Set Radio. Every stage has many spots to find where you can paint graffiti. – The goal is to get your name up, your name up on the wall. – You can grind, slide, jump, trick and airdash to move around – Each stage is a neighborhood that represents one time of day. – In the game you can choose a character from your crew and explore the three-dimensional streets freely. Start your own cypher and dance, paint, trick, face off with the cops and stake your claim to the extrusions and cavities of a sprawling metropolis in an alternate future set to the musical brainwaves of Hideki Naganuma. In a world from the mind of Dion Koster, where self-styled crews are equipped with personal boostpacks, new heights of graffiti are reached. “ Team Reptile brings you Bomb Rush Cyberfunk, 1 second per second of highly advanced funkstyle. Yet here are the facts we do know, taken from the game’s description up on the Steam store. Other than a short 14-second announcement video and a couple of screenshots, not much else is currently known about this new project. It looks so familiar in fact that at first glance you’d believe this to be a fully authorised instalment to the popular series, however (believe it or not) this has nothing to do with the original or Sega. Continued abuse of our services will cause your IP address to be blocked indefinitely.BY LUKE MARSHALL: Indie developers Team Reptile have just announced a new game which appears to be a spiritual successor to cult-classic, Jet Set Radio.Įntitled Bomb Rush Cyberfunk, the game features a familiar cell shading art style and a return to the world of inner-city graffiti tagging. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. 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Botox And Fillers Specialist - Chandler, Az Things To Know Before You Get This You will experience skin treatments that activate your skin cells and accelerate the procedure of natural regrowth. Our med medical spa, Vibrant Skin, Hair and Laser Center, is situated in Chandler. Lots of customers have regular or oily skin some may have had dry skin problems. Everything about Juvederm Volbella Lip FillerĪt Vibrant Skin, Hair and Laser Center, we use specialists who will assist you take on all your skin issues. Plus, we make every effort to provide customers ingenious anti-aging injections, or skin enhancement solutions for the perfect non-surgical filler mix. At our Medical spa we remain up to date on the most current trends in cosmetic treatments so whatever you require is now at your fingertips. It is the fastest-growing cosmetic treatment in the US. Restylane works by bring back the quantity of collagen, elastin, and hyaluronic acid in the skin. Utilizing Dysport is a safe method of getting rid of wrinkles and fine lines without stressing over the long-lasting effects of cosmetic surgeries. Dysport not just reduces the look of fine lines, wrinkles, and other indications of aging, but it also supplies a natural and healthy glow to the skin that lasts for a very long time. The 3-Minute Rule for 325 Dermal Fillers Doctors & Clinics In Phoenix, AzĪging skin can not operate appropriately without correct supply of collagen and elastin. 6 However, no selective Met inhibitors, such as SU11274 and Tepotinib, have been proven despite the encouraging wave of recent drug approvals for HCC. Currently, at least 17 Met inhibitors, including JNJ-38877605, GEN-203, and ARQ-197, are undergoing clinical trials. Various cytoplasmic effectors, including PI3K, Ras, PLC-γ, Shc, and SHP2, are recruited to the docking site and subsequently activated. 2, 3, 4, 5 Upon activation, the tyrosine residues Y1234 and Y1235 in the kinase domain of Met are phosphorylated, which leads to auto-phosphorylation of the C-terminal multi-substrate docking site, Y1349, and Y1356. 1 High hepatocyte growth factor (HGF) levels in serum or overexpression of Met in hepatocellular carcinoma (HCC) are closely associated with early recurrence, 2 and patients with high expression levels of Met usually have low 5-year survival rates after curative surgical resection. Liver cancer is the second leading cause of cancer death worldwide because of the high rate of metastasis. These findings reveal a novel and noncanonical pathway of Met receptor tyrosine kinase in the regulation of mitochondrial activities, which may provide a therapeutic target for metastatic HCC. Fragmented mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma (HCC) cells both in vitro and in vivo. Fis1 pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein-1 (Drp1) to mitochondria. Mechanically, we found that Met directly phosphorylated outer mitochondrial membrane protein Fis1 at Tyr38 (Fis1 pY38). The contacts between activated Met kinase and mitochondria formed dramatically, and an intact HGF/Met axis was necessary for dysregulated mitochondrial fission and cancer cell movements. Here, using structured illumination microscopy (SIM) and high spatial and temporal resolution live cell imaging, we identified mitochondrial trafficking of receptor tyrosine kinase Met. Dysregulated mitochondrial dynamics are responsible for the progression and metastasis of many cancers. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network. All rights reserved.Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. We suggest that deeper understanding of the regulatory mechanisms within this system and downstream implications could benefit in understanding and intervention of these conditions.Īge-related disease Aging Fission Fusion Mitochondrial dynamics.Ĭopyright © 2020 The Author(s). Finally, we discuss the current evidence implicating these processes in age-related human pathologies, such as neurodegenerative or cardio-metabolic diseases. Here, we discuss the mechanisms of mitochondrial fission and fusion, the current evidence of their role in aging of multicellular organisms, and how these connect to cell cycle regulation, quality control, and transmission of energy status. There does exist, however, a large body of evidence connecting mitochondrial dynamics to other aging-related cellular processes and implicates them in a number of human diseases. While many mitochondrial processes are already characterized in relation to aging, specific evidence in multicellular organisms causally linking mitochondrial dynamics to the regulation of lifespan is limited. Mitochondria separate and merge using fission and fusion processes in response to changes in energy and stress status. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. The mitochondria is the major hub to convert energy for cellular processes. Xerox sues Apple over the user interface of the Mac and the Apple Lisa. In 1995, the US Supreme Court confirms the rejection of the appeal. Microsoft prevails in court in 1992 and also wins the appeal two years later. Apple is unable to stop the further development of Windows. A protracted legal battle ensues, with Apple unable to stop the further development of Windows. Microsoft counters the counterclaim and refers to the license agreement from the year 1985. The greatly improved Windows 2.03 is released.Īpple sues Microsoft over various similarities between Windows and Mac OS. In August 1987, Microsoft releases its first version of Windows, but it is virtually unusable. Ross Perot invests $20 million in NeXT, Inc. The installed base of Mac users grows to 1 million users. Both machines allow expansion slots to be added to Macs for the first time. At the same time, Apple launches the Mac SE with the classic all-in-one design. The Mac II can also support color displays. 1987Īpple builds the Mac II, the first Mac that does not rely on an all-in-one design. At the end of 1985 Microsoft publishes its first Windows version 1.01. Microsoft licenses some of the Mac technologies to develop its Office package for the Mac. Some models are converted and sold as the Mac XL. I AM BUT 30 AND WANT STILL TO CONTRIBUTE AND ACHIEVE.“ - Steven P. “AS YOU KNOW, THE COMPANY’S RECENT REORGANIZATION LEFT ME WITH NO WORK TO DO AND NO ACCESS EVEN TO REGULAR MANAGEMENT REPORTS. and uses the proceeds from stock sales to buy Lucas Film’s animation division, creating Pixar. Jobs leaves Apple and founds the computer company NeXT Inc. After a power struggle with then Apple CEO John Sculley, Steve Jobs is relieved of his operational duties. Sales of the Mac falter because too few applications are available. With the different Apple II series, Apple does the main part of its business. And many customers do not bring the computers back to the stores in perfect condition, incurring significant repair costs.Īpril 24, 1984: The Apple IIc is introduced. For one thing, too few Macs are initially available. Although the promotion was unique and innovative up to that point, the program does not show the desired success. Prospective customers can take a Mac home from a retailer for 24 hours to try it out, free of charge. The Apple Lisa 2 retails for $3,495.Īpple launches the “Test a Mac” promotional program. January 24, 1984: The Mac is launched for $2,495. The Chiat/Day agency calculated that the “1984” spot generated over five million dollars worth of free publicity. The ad not only cleared Cannes, but was repeatedly aired by TV stations in the news. On January 22, 1984, six weeks later, the commercial then aired during a commercial break in SuperBowl XVIII. In order to qualify for the Cannes Advertising Film Festival, Apple had the famous Big Brother commercial for the Mac in December 1983 on TV station KMVT in Twin Apple Lisa (1983) Falls (Idaho). “Do you want to sell sugar water for the rest of your life, or do you want to take a chance and change the world?” was Jobs’ legendary question, which ultimately won Sculley over as Apple CEO. In April, Steve Jobs convinced Pepsico president John Sculley to join Apple. As sales falter, the price drops to $6,995 by the end of the year.Īt Apple, the previously competing Lisa and Mac divisions are merged. The Apple Lisa hits the market on Janufor $9,995. Jef Raskin quits after being pushed out of the Macintosh project by Steve Jobs. Steve Wozniak crashes a private plane and partially retires from Apple. Apple “welcomes” IBM to the PC market in an ad. Steve Jobs takes over the Macintosh project. The Apple IPO makes some rich, others mad. On December 12, 1980, Apple goes public, floating 4.6 million shares of stock at $22 per share. It includes several features that Apple employees have seen at Xerox PARC. Specifications for the Apple Lisa are developed. These include the Xerox Alto, the first personal computer with a graphical user interface, the computer mouse, and object-oriented programming. Steve Jobs and his team at Apple visit the legendary research institute Xerox PARC, where they see several novel technologies. The computer was supposed to be ready in March 1981. In July 1979, the project for the Apple Lisa is started. In June 1979, the Apple II+ is launched for $1,195. Raskin leaves Apple in 1982, even before the Mac was launched, because he would not accept Steve Jobs’ meddling. This would later become the Macintosh project. A research project for a new low-cost computer is started under the direction of Jef Raskin. In this picture, you can see a small telescope, which is located on a tripod. Telescopes come in a variety of forms, and nowadays, there are even huge telescopes that can be used to view distant galaxies. Then telescopes began to be used in order to examine space objects. Initially, telescopes were used by sailors during the voyage to see from afar the ships that were approaching them. This device allows you to observe even very distant objects. With the help of a telescope, you can observe any celestial bodies and admire their beauty. The telescope is an optical instrument for observing the stars, planets, and their satellites. The lesson consists of nine simple steps that you can easily follow.Įspecially for beginners, I have prepared a new lesson in which I will show you how to draw a telescope step by step. Sketching equipment: Clipboard black A4 160 gsm card soft pastels white gel pen cotton bud small paper tortillion red headlight for dark adaption.In this drawing lesson, I want to show you how to draw a telescope. I used an 8-inch Dobsonian with a Meade Plössl 20mm eyepiece, giving a magnification of 60x. Observing equipment: Binoculars on a tripod or a telescope of any size. Include the date, time in UT, instrument, eyepiece, magnification and sky conditions on your page. In daylight you can tidy up any stars by hand or with Photoshop to complete the drawing. Some stars are visible within the nebula and these can be added after you have finished sketching it. Any errors can be adjusted with a cotton bud.Edges can be sharpened using a small tortillion or, if you don’t have one, a toothpick or cocktail stick.ĭon’t overdo either the nebula’s angular structure or its sweeping curves only draw what you see. Use a cotton bud to spread the shape of the nebula around the Trapezium Cluster. Note the sweeping arcs of gas and dust and any darker areas. Observe the shape of the nebula, paying particular attention to differences in its structure and the areas of brightness as it wraps around the Trapezium Cluster.Īdd a little white pastel over the grey and blend them together to show this light. Start by rubbing some grey, white and black pastel onto the edge of the page, as this will enable you to pick up pastel on a cotton bud and adjust the tone as needed. Deirdre's finished sketch of the Orion Nebula, 11/ from Bray, Co. Adding the stars is all about accurate placement the nebula, on the other hand, is about structure and tone. When most of the stars are placed, turn to the nebula. If your telescope doesn’t have a drive then you’ll have to continuously realign your field of view, and starting your sketch this way helps you find your way back to the star field to continue drawing. The longer you hold the gel pen against the card the brighter the stars you’ll make. Read Deirdre's guide to sketching the Moon.I used a white gel pen to place a bright star just inside the top of my sketching circle, then added the dim stars near the bottom. Start by observing the positions of the stars in the field of view, using the triangles their locations form as a reference. One of the exciting things about sketching M42, the Orion Nebula, in particular is that you’re observing a nursery for unborn stars and planets. Nebulae are fantastic objects to sketch, and not just for the enjoyment of the finished article. |
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